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- 王琛 副主任医师
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所在医院：上海交通大学医学院附属第九人民医院
所在科室：整复外科
擅 长：擅长内容：眼、鼻整形、微创注射、抽脂塑形；面颈部瘢痕畸形的修复；各类鼻畸形、鼻缺损的修复和再造；乳房整形；腹壁缺损的修复和再造；小儿颈部瘢痕的序列治疗
简 介：王琛，男，医学博士，硕士生导师。入选九院第五届青年骨干、交大医学院青年教师。师从资深整形外科钱云良和微整形王丹茹，主要工作涉及瘢痕修复、唇鼻...
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医生介绍
王琛，男，医学博士，硕士生导师。入选九院第五届青年骨干、交大医学院青年教师。师从资深整形外科钱云良和微整形王丹茹，主要工作涉及瘢痕修复、唇鼻再造、腹壁缺损修复和脂肪干细胞治疗等领域。独立承担包括自然科学基金在内的5项课题，参与“973”、“863”计划、自然科学基金面上项目以及上海市学科带头人计划等多个项目的研究。近五年在Biomaterials、Tissue Eng、Am J Surg等刊物上发表SCI论文十余篇，其中部分文章作为Feature article发表。参与编写专著2部。临床上除了传承传统的修复手术之外，还对外伤后歪鼻畸形、鼻再造（亚单位再造）、小儿烧伤后颈部瘢痕挛缩的修复进行了一定的改进，并针对小儿的生长发育特点，初步提出了小儿颈部瘢痕挛缩的分类和治疗策略（序列治疗）并进一步完善鼻翼缺损、鼻再造分型和治疗策略，从而形成以大数据医学和精准医学为指导，以个性化的治疗方式使每个患者得到更好的治疗效果。在美容整形外科方面，在微整形王丹茹的指导下，根据求美者的要求，用个性化的方式，用小创伤达到理想的整形美容效果。
科研成果：
主要发表文章：
1. Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L. A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells, Biomaterials, 2010,31(4):621-630.
2. Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L. Differentiation of adipose derived stem cells into contractile smooth muscle cells induced by TGF-β1 and BMP4, Tissue Eng Part A, 2010,16(4):1201-1213.
3. Yin S, Cen L, Wang C, Zhao G, Sun J, Liu W, Cao Y, Cui L. Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage derived morphogenetic protein1, Tissue Eng Part A,2010,16(5):1633-1643.
4. Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells, Tissue Eng Part A, 2013, 19(3-4):415-425.
5. Wang X, Qian Y, Jin R, Wo Y, Chen J, Wang C, Wang D. Effects of TRAP-1-like protein (TLP) gene on collagen synthesis induced by TGF-β/Smad signaling in humandermal fibroblasts, PLoS One,2013,8(2):e55899.
6. Gu H, Xiong Z, Xu J, Li G, Wang C. Clinical and anatomical study of the distally based lesser saphenous veno-lateral sural neurocutaneous flap for lower extremity coverage, J Orthop Sci, 2013,18(5):740-748. (corresponding author)
7. Gong L, Wang C, Sun Q, Li G, Wang D. Effects of human adipose derived stem cells on the viability of rabbit random pattern flaps, Cytotherapy, 2014,16(4):496-507. (co-author)
8. Gong L, Zhou X, Wu Y, Zhang Y, Wang C, Zhou H, Guo F, Cui L. Proteomic Analysis Profile of Engineered Articular Cartilage with Chondrogenic Differentiated Adipose Tissue-Derived Stem Cells Loaded Polyglycolic Acid Mesh for Weight-Bearing Area Defect Repair,Tissue Eng Part A, 2014,20(3-4):575-87.
9. Gu H, Xiong Z, Yin X, Li B, Mei N, Li G, Wang C. Bone regeneration in a rabbit ulna defect model: use of allogeneic adipose-derived stem cells with low immunogenicity, Cell Tissue Res,2014,358(2):453-64. (corresponding author)
10. Wang C, Xiong Z, Xu J, Zhang L, Huang H, Li G. The distally based lateral sural neuro-lesser saphenous veno-fasciocutaneous flap: anatomical basis and clinical applications, J Orthop Traumatol, 2014,15(3):215-23.
11. Wang C, Cai Y, Zhang Y, Xiong Z, Li G, Cui L. Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression. PLoS One. 2014;9(6):e100818.
12.Wang X, Chu J, Wen C, Fu S, Qian Y, Wo Y, Wang C, Wang D. Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-β/Smad signaling in hypertrophic scar fibroblasts. Exp Cell Res.2015;332(2):202-11. (corresponding author)
13. Wen C, Yan H, Fu S, Qian Y, Wang D, Wang C, Allogeneic Adipose-derived Stem Cells Regenerate Bone in a Critical-sized Ulna Segmental Defect. Exp Biol Med . 2015 Mar 27. (corresponding author)
14． Lv Y, Cao D, Guo F, Qian Y, Wang C, Wang D. Abdominal wall reconstruction using a combination of free tensor fasciae lata and anterolateral thigh myocutaneous flap: a prospective study in 16 patients.Am J Surg. 2015;210(2):365-73. (corresponding author)
15. Zhou R, Zhang Q, Zhang Y, Fu S, Wang C.Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Exp Cell Res. 2015 Oct 20. (corresponding author)
16. 王琛，徐静，张莉，熊竹友，李光早。指背血管蒂岛状皮瓣应用解剖。 中国临床解剖学杂志。2006;24(5):514-517。
17. 王琛，郭芳芳，张昀，等。 应用脂肪干细胞构建小口径组织工程血管平滑肌层的实验研究. 组织工程与重建外科杂志. 2012,8(5):249-255
18.熊竹友，方小魁，徐静，张莉，王琛，李光早。同种异体脂肪干细胞复合脱钙骨修复大鼠尺骨缺损。组织工程与重建外科杂志,2013,9(5):245-251.（通信作者）
19. 张奇，王琛。microRNA-21调控TGF-β通路促进增生性瘢痕形成的机制研究。组织工程与重建外科杂志,2014,10(6):318-323. （通信作者）
20．张奇，王琛。VSD技术临床应用研究现状. 中华医学杂志，2014,11(10):52-56。（通信作者）
21. 张奇，王琛。miRNA参与调控皮肤创伤修复的发生发展。医学美学美容，2015,1(1):35-36。（通信作者）
承担课题
1. 上海市自然科学基金：应用脂肪干细胞构建双层结构的组织工程化血管修复小口径动脉缺损的实验研究（11ZR1420300）
2. 自然科学基金青年基金：力学刺激诱导miR-100诱导脂肪干细胞向平滑肌细胞分化的作用和机制（810201204）
3. 上海高校青年教师科研专项基金：miR-21调控Smad7基因表达在增生性瘢痕形成中的作用及机制（ZZjdyx12100）
4. 上海交大医学院青年教师人才计划：miR-31/FIH轴调控HIF-1α通路促进增生性瘢痕发展的机制研究
5. 第五届“九院优青培养计划”： miR-21调控TGF-β通路在增生性疤痕形成中的作用及机制
科研成果：
主要发表文章：
1. Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L. A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells, Biomaterials, 2010,31(4):621-630.
2. Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L. Differentiation of adipose derived stem cells into contractile smooth muscle cells induced by TGF-β1 and BMP4, Tissue Eng Part A, 2010,16(4):1201-1213.
3. Yin S, Cen L, Wang C, Zhao G, Sun J, Liu W, Cao Y, Cui L. Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage derived morphogenetic protein1, Tissue Eng Part A,2010,16(5):1633-1643.
4. Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells, Tissue Eng Part A, 2013, 19(3-4):415-425.
5. Wang X, Qian Y, Jin R, Wo Y, Chen J, Wang C, Wang D. Effects of TRAP-1-like protein (TLP) gene on collagen synthesis induced by TGF-β/Smad signaling in humandermal fibroblasts, PLoS One,2013,8(2):e55899.
6. Gu H, Xiong Z, Xu J, Li G, Wang C. Clinical and anatomical study of the distally based lesser saphenous veno-lateral sural neurocutaneous flap for lower extremity coverage, J Orthop Sci, 2013,18(5):740-748. (corresponding author)
7. Gong L, Wang C, Sun Q, Li G, Wang D. Effects of human adipose derived stem cells on the viability of rabbit random pattern flaps, Cytotherapy, 2014,16(4):496-507. (co-author)
8. Gong L, Zhou X, Wu Y, Zhang Y, Wang C, Zhou H, Guo F, Cui L. Proteomic Analysis Profile of Engineered Articular Cartilage with Chondrogenic Differentiated Adipose Tissue-Derived Stem Cells Loaded Polyglycolic Acid Mesh for Weight-Bearing Area Defect Repair,Tissue Eng Part A, 2014,20(3-4):575-87.
9. Gu H, Xiong Z, Yin X, Li B, Mei N, Li G, Wang C. Bone regeneration in a rabbit ulna defect model: use of allogeneic adipose-derived stem cells with low immunogenicity, Cell Tissue Res,2014,358(2):453-64. (corresponding author)
10. Wang C, Xiong Z, Xu J, Zhang L, Huang H, Li G. The distally based lateral sural neuro-lesser saphenous veno-fasciocutaneous flap: anatomical basis and clinical applications, J Orthop Traumatol, 2014,15(3):215-23.
11. Wang C, Cai Y, Zhang Y, Xiong Z, Li G, Cui L. Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression. PLoS One. 2014;9(6):e100818.
12.Wang X, Chu J, Wen C, Fu S, Qian Y, Wo Y, Wang C, Wang D. Functional characterization of TRAP1-like protein involved in modulating fibrotic processes mediated by TGF-β/Smad signaling in hypertrophic scar fibroblasts. Exp Cell Res.2015;332(2):202-11. (corresponding author)
13. Wen C, Yan H, Fu S, Qian Y, Wang D, Wang C, Allogeneic Adipose-derived Stem Cells Regenerate Bone in a Critical-sized Ulna Segmental Defect. Exp Biol Med . 2015 Mar 27. (corresponding author)
14． Lv Y, Cao D, Guo F, Qian Y, Wang C, Wang D. Abdominal wall reconstruction using a combination of free tensor fasciae lata and anterolateral thigh myocutaneous flap: a prospective study in 16 patients.Am J Surg. 2015;210(2):365-73. (corresponding author)
15. Zhou R, Zhang Q, Zhang Y, Fu S, Wang C.Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Exp Cell Res. 2015 Oct 20. (corresponding author)
16. 王琛，徐静，张莉，熊竹友，李光早。指背血管蒂岛状皮瓣应用解剖。 中国临床解剖学杂志。2006;24(5):514-517。
17. 王琛，郭芳芳，张昀，等。 应用脂肪干细胞构建小口径组织工程血管平滑肌层的实验研究. 组织工程与重建外科杂志. 2012,8(5):249-255
18.熊竹友，方小魁，徐静，张莉，王琛，李光早。同种异体脂肪干细胞复合脱钙骨修复大鼠尺骨缺损。组织工程与重建外科杂志,2013,9(5):245-251.（通信作者）
19. 张奇，王琛。microRNA-21调控TGF-β通路促进增生性瘢痕形成的机制研究。组织工程与重建外科杂志,2014,10(6):318-323. （通信作者）
20．张奇，王琛。VSD技术临床应用研究现状. 中华医学杂志，2014,11(10):52-56。（通信作者）
21. 张奇，王琛。miRNA参与调控皮肤创伤修复的发生发展。医学美学美容，2015,1(1):35-36。（通信作者）
承担课题
1. 上海市自然科学基金：应用脂肪干细胞构建双层结构的组织工程化血管修复小口径动脉缺损的实验研究（11ZR1420300）
2. 自然科学基金青年基金：力学刺激诱导miR-100诱导脂肪干细胞向平滑肌细胞分化的作用和机制（810201204）
3. 上海高校青年教师科研专项基金：miR-21调控Smad7基因表达在增生性瘢痕形成中的作用及机制（ZZjdyx12100）
4. 上海交大医学院青年教师人才计划：miR-31/FIH轴调控HIF-1α通路促进增生性瘢痕发展的机制研究
5. 第五届“九院优青培养计划”： miR-21调控TGF-β通路在增生性疤痕形成中的作用及机制